Citing Myokit
If you're using Myokit in your research, please cite:
Myokit: A simple interface to cardiac cellular electrophysiology
2016
Progress in Biophysics and Molecular Biology
Volume 120, issues 1-3, pages 100-114
doi: 10.1016/j.pbiomolbio.2015.12.008
Example files for this publication
All feedback, positive and negative, is welcome! If you are using Myokit for research or education, please let us know by emailing Michael Clerx (michael@myokit.org).
Publications using Myokit
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Disruption of a Conservative Motif in the C-Terminal Loop of the KCNQ1 Channel Causes LQT Syndrome 2022 International journal of molecular sciences doi: 10.3390/ijms23147953
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A parameter representing missing charge should be considered when calibrating action potential models 2022 Frontiers in Physiology doi: 10.3389/fphys.2022.879035
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Integrative Computational Modeling of Cardiomyocyte Calcium Handling and Cardiac Arrhythmias Current Status and Future Challenges 2022 Cells doi: 10.3390/cells11071090
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Treatment response prediction: Is model selection unreliable? 2022 bioRxiv doi: 10.1101/2022.03.19.483454
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Individual Contributions of Cardiac Ion Channels on Atrial Repolarization and Reentrant Waves: A Multiscale In-Silico Study 2022 Journal of Cardiovascular Development and Disease doi: 10.3390/jcdd9010028
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Spatiotemporal approximation of cardiac activation and recovery isochrones 2021 Journal of Electrocardiology doi: 10.1016/j.jelectrocard.2021.12.007
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Anatomical Model of Rat Ventricles to Study Cardiac Arrhythmias under Infarction Injury 2021 Mathematics doi: 10.3390/math9202604
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Sex Differences in Drug-Induced Arrhythmogenesis 2021 Frontiers in Physiology doi: 10.3389/fphys.2021.708435
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Electrophysiological characterization of the hERG R56Q LQTS variant and targeted rescue by the activator RPR260243 2021 Journal of General Physiology doi: 10.1085/jgp.202112923
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Immediate and delayed response of simulated human atrial myocytes to clinically-relevant hypokalemia 2021 Frontiers in Physiology doi: 10.3389/fphys.2021.651162
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Cellular Mechanisms of the Anti-Arrhythmic Effect of Cardiac PDE2 Overexpression 2021 International journal of molecular sciences doi: 10.3390/ijms22094816
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Novel insights into the electrophysiology of murine cardiac macrophages: relevance of voltage-gated potassium channels 2021 Cardiovascular Research doi: 10.1093/cvr/cvab126
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Caveolin3 Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes 2021 Circulation Research doi: 10.1161/CIRCRESAHA.119.316547
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Evolution of mathematical models of cardiomyocyte electrophysiology 2020 Mathematical Biosciences doi: 10.1016/j.mbs.2021.108567
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Beta-Adrenergic Receptor Stimulation Limits the Cellular Proarrhythmic Effects of Chloroquine and Azithromycin 2020 Frontiers in Physiology doi: 10.3389/fphys.2020.587709
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Acute effects of alcohol on cardiac electrophysiology and arrhythmogenesis: Insights from multiscale in silico analyses 2020 Journal of Molecular and Cellular Cardiology doi: 10.1016/j.yjmcc.2020.07.007
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In-silico analysis of aging mechanisms of action potential remodeling in human atrial cardiomyocites 2020 Longevity Interventions 2020 doi: 10.1051/bioconf/20202201025
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Self-restoration of cardiac excitation rhythm by anti-arrhythmic ion channel gating 2020 eLife doi: 10.7554/eLife.55921
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Reducing complexity and unidentifiability when modelling human atrial cells 2020 Philosophical Transactions of the Royal Society A doi: 10.1098/rsta.2019.0339
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Considering discrepancy when calibrating a mechanistic electrophysiology model 2020 Philosophical Transactions of the Royal Society A doi: 10.1098/rsta.2019.0349
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Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments 2020 Philosophical Transactions of the Royal Society A doi: 10.1098/rsta.2019.0348
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Calibration of ionic and cellular cardiac electrophysiology models 2020 WIREs Systems Biology and Medicine doi: 10.1002/wsbm.1482
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Temporal irregularity quantification and mapping of optical action potentials using wave morphology similarity 2020 Progress in Biophysics and Molecular Biology doi: 10.1016/j.pbiomolbio.2019.12.004
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Rapid characterisation of hERG channel kinetics II: temperature dependence 2019 Biophysical Journal doi: 10.1016/j.bpj.2019.07.030
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Rapid characterisation of hERG channel kinetics I: using an automated high-throughput system 2019 Biophysical Journal doi: 10.1016/j.bpj.2019.07.029
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Analysis of approaches to building a probability density function for the mathematical model parameters of rat atrial cardiomyocytes 2019 AIP Conference Proceedings doi: 10.1063/1.5134405
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In silico study of the aging of cardiomyocytes in human and canine atriums 2019 AIP Conference Proceedings doi: 10.1063/1.5134382
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Unsupervised learning to analysis of population of models in computational electrophysiological studies 2019 SIBIRCON doi: 10.1109/SIBIRCON48586.2019.8958141
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Maastricht antiarrhythmic drug evaluator (MANTA): a computational tool for better understanding of antiarrhythmic drugs 2019 Pharmacological Research doi: 10.1016/j.phrs.2019.104444
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Modelling the Electrical Activity of the Heart 2019 In: Cardiovascular Computing - Methodologies and Clinical Applications doi: 10.1007/978-981-10-5092-3_10
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Rethinking multiscale cardiac electrophysiology with machine learning and predictive modelling 2019 Computers in Biology and Medicine doi: 10.1016/j.compbiomed.2018.10.015
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Myocyte Remodeling Due to Fibro-Fatty Infiltrations Influences Arrhythmogenicity 2018 Frontiers in Physiology doi: 10.3389/fphys.2018.01381
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Muscarinic type-1 receptors contribute to IK,ACh in human atrial cardiomyocytes and are upregulated in patients with chronic atrial fibrillation 2017 International Journal of Cardiology doi: 10.1016/j.ijcard.2017.12.050
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Tailoring Mathematical Models to Stem-Cell Derived Cardiomyocyte Lines Can Improve Predictions of Drug-Induced Changes to Their Electrophysiology 2017 Frontiers in Physiology doi: 10.3389/fphys.2017.00986
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Spatial Patterns of Excitation at Tissue and Whole Organ Level Due to Early Afterdepolarizations 2017 Frontiers in Physiology doi: 10.3389/fphys.2017.00404
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Beta-adrenergic receptor stimulation inhibits proarrhythmic alternans in post-infarction border zone cardiomyocytes 2017 AJPHeart doi: 10.1152/ajpheart.00094.2017
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Inverse remodelling of K2P3.1 K+ channel expression and action potential duration in left ventricular dysfunction and atrial fibrillation: implications for patient-specific antiarrhythmic drug therapy 2017 European Heart Journal doi: 10.1093/eurheartj/ehw559
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Physiology-based Regularization of the Electrocardiographic Inverse Problem 2017 Medical & Biological Engineering & Computing doi: 10.1007/s11517-016-1595-5
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Fhf2 gene deletion causes temperature-sensitive cardiac conduction failure 2016 Nature Communications doi: 10.1038/ncomms12966
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In silico evaluation of the potential antiarrhythmic effect of Epigallocatechin-3-Gallate on cardiac channelopathies 2016 Computational and Mathematical Methods in Medicine doi: 10.1155/2016/7861653
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Bioelectric memory: modeling resting potential bistability in amphibian embryos and mammalian cells 2015 Theoretical Biology and Medical Modelling doi: 10.1186/s12976-015-0019-9
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Applying novel identification protocols to Markov models of INa 2015 Computing in Cardiology 2015 Download pre-print
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Reducing run-times of excitable cell models by replacing computationally expensive functions with splines 2014 21st International Symposium on Mathematical Theory of Networks and Systems, July 7-11, 2014, University of Groningen, Groningen, The Netherlands Download author's copy (Copyright IEEE)
Education using Myokit
I am proud and happy to report that Myokit is being used as an educational tool to let students explore cardiac cellular electrophysiology!
The following people have told me they use Myokit in their classes:
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Dr. Mohamed-Yassine Amarouch has used Myokit to teach practical classes on physiology at the University of Sidi Mohamed Ben Abdellah of Fès, Multidisciplinary faculty of Taza.
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Dr. Hannes Todt used Myokit in a course on "Science and Medicine", at the Medical University of Vienna. Myokit was used to simulate experiments which the students were then asked to evaluate.